Prof. Dr. Kristian Franze
Institute for Medical Physics and Microtissue Engineering
Max-Planck-Zentrum für Physik und Medizin
Friedrich-Alexander-Universität Erlangen-Nürnberg
kristian.franze@fau.de
See my profile at FAU
Neuronal Mechanics, Mechanobiology, Developmental biology, Neuroscience, Regenerative medicine
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#Humboldtian: Andrea Bréard and Kristian Franze: Alexander von Humboldt Professorship
Kristian Franze. Humboldtian, May 2022
Publications
2025
Dynamic traction force measurements of migrating immune cells in 3D matrices
(2025)
DOI: 10.1101/2022.11.16.516758 , , , , , , , , , , , , , :
Environmental stiffness regulates neuronal maturation via Piezo1-mediated TTR activity
(2025)
DOI: 10.1101/2024.07.25.605128 , , , , , , , , , , , , :
Long-range chemical signallingin vivois regulated by mechanical signals
(2025)
DOI: 10.1101/2024.02.15.580459 , , , , , , , :
Eph/ephrin signalling in the developing brain is regulated by tissue stiffness
(2025)
DOI: 10.1101/2024.02.15.580461 , :
2024
Sensing the force in living embryos
In: Nature Materials (2024)
ISSN: 1476-1122
DOI: 10.1038/s41563-024-02033-5 :
Tensed axons are on fire
In: Proceedings of the National Academy of Sciences of the United States of America 121 (2024), p. e2321811121
ISSN: 0027-8424
DOI: 10.1073/pnas.2321811121 :
2023
Mechanical behavior of the hippocampus and corpus callosum: An attempt to reconcile ex vivo with in vivo and micro with macro properties
In: Journal of the Mechanical Behavior of Biomedical Materials 138 (2023), Article No.: 105613
ISSN: 1751-6161
DOI: 10.1016/j.jmbbm.2022.105613 , , , , , , , , , , , , , :
Regenerative capacity of neural tissue scales with changes in tissue mechanics post injury
In: Biomaterials 303 (2023), Article No.: 122393
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2023.122393 , , , , , :
Plakoglobin is a mechanoresponsive regulator of naive pluripotency
In: Nature Communications 14 (2023), Article No.: 4022
ISSN: 2041-1723
DOI: 10.1038/s41467-023-39515-0 , , , , , , , , , , , , , , , , , :
Effective cell membrane tension is independent of polyacrylamide substrate stiffness
In: PNAS Nexus 2 (2023), Article No.: pgac299
ISSN: 2752-6542
DOI: 10.1093/pnasnexus/pgac299 , , , , , , , , :
Constriction imposed by basement membrane regulates developmental cell migration
In: Plos Biology 21 (2023), Article No.: e3002172
ISSN: 1544-9173
DOI: 10.1371/journal.pbio.3002172 , , , , , :
Mechanics in the nervous system: From development to disease
In: Neuron (2023)
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2023.10.005 , :
The mechanical regulation of Eph/ephrin signaling in the developing brain
In: Biophysical Journal 122 (2023), p. 269a
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2022.11.1540 , , :
Brain tissue mechanics is governed by microscale relations of the tissue constituents
In: Biomaterials 301 (2023), Article No.: 122273
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2023.122273 , , , :
2022
Prevention of the foreign body response to implantable medical devices by inflammasome inhibition
In: Proceedings of the National Academy of Sciences of the United States of America 119 (2022), p. e2115857119
ISSN: 0027-8424
DOI: 10.1073/pnas.2115857119 , , , , , , , , , , , , :
Unrestrained growth of correctly oriented microtubules instructs axonal microtubule orientation
In: eLife 11 (2022)
ISSN: 2050-084X
DOI: 10.7554/eLife.77608 , , :
Retinal regions shape human and murine Muller cell proteome profile and functionality
In: Glia (2022)
ISSN: 0894-1491
DOI: 10.1002/glia.24283 , , , , , , , , , , , , , , , :
Axons in the Chick Embryo Follow Soft Pathways Through Developing Somite Segments
In: Frontiers in Cell and Developmental Biology 10 (2022), Article No.: 917589
ISSN: 2296-634X
DOI: 10.3389/fcell.2022.917589 , , , , :
Cell surface fluctuations regulate early embryonic lineage sorting
In: Cell 185 (2022), p. 777-793.e20
ISSN: 0092-8674
DOI: 10.1016/j.cell.2022.01.022 , , , , , , , , , , , , , , , , :
2021
StemBond hydrogels control the mechanical microenvironment for pluripotent stem cells
In: Nature Communications 12 (2021), Article No.: 6132
ISSN: 2041-1723
DOI: 10.1038/s41467-021-26236-5 , , , , , , , , , , , , , :
Soft Polydimethylsiloxane-Supported Lipid Bilayers for Studying T Cell Interactions.
In: Biophysical Journal 120 (2021), p. 35-45
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2020.11.021 , , , , , , , , , , :
Theory for Durotactic Axon Guidance
In: Physical Review Letters 126 (2021), Article No.: 118101
ISSN: 0031-9007
DOI: 10.1103/PhysRevLett.126.118101 , , :
Vinculin is required for neuronal mechanosensing but not for axon outgrowth
In: Experimental Cell Research 407 (2021), Article No.: 112805
ISSN: 0014-4827
DOI: 10.1016/j.yexcr.2021.112805 , , , , , , , , , :
2020
Towards brain-tissue-like biomaterials
In: Nature Communications 11 (2020), Article No.: 3423
ISSN: 2041-1723
DOI: 10.1038/s41467-020-17245-x , , , :
Mechanochemical Crosstalk Produces Cell-Intrinsic Patterning of the Cortex to Orient the Mitotic Spindle.
In: Current Biology 30 (2020), p. 3687-3696.e4
ISSN: 0960-9822
DOI: 10.1016/j.cub.2020.06.098 , , , , , , , , , , :
Integrating Chemistry and Mechanics: The Forces Driving Axon Growth
DOI: 10.1146/annurev-cellbio-100818-125157 :
Mechanical Regulation of Neurite Polarization and Growth: A Computational Study
In: Biophysical Journal 118 (2020), p. 1914-1920
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2020.02.031 , , :
Defining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis
In: Cell Stem Cell 26 (2020), p. 277-293.e8
ISSN: 1934-5909
DOI: 10.1016/j.stem.2020.01.002 , , , , , , , , , , , :
The Costs of Close Contacts: Visualizing the Energy Landscape of Cell Contacts at the Nanoscale
In: Biophysical Journal 118 (2020), p. 1261-1269
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2020.01.019 , , , , , , , , , , , :
Spatial heterogeneity of cell-matrix adhesive forces predicts human glioblastoma migration
2 (2020), Article No.: vdaa081
ISSN: 2632-2498
DOI: 10.1093/noajnl/vdaa081 , , , , , , , :
Cortical cell stiffness is independent of substrate mechanics
In: Nature Materials (2020)
ISSN: 1476-1122
DOI: 10.1038/s41563-020-0684-x , , , , , , , , :
2019
Tissue stiffness at the human maternal-fetal interface
In: Human Reproduction 34 (2019), p. 1999-2008
ISSN: 0268-1161
DOI: 10.1093/humrep/dez139 , , , , , , , , , :
All-Optical Detection of Neuronal Membrane Depolarization in Live Cells Using Colloidal Quantum Dots
In: Nano Letters (2019)
ISSN: 1530-6984
DOI: 10.1021/acs.nanolett.9b03026 , , , , , , , , , :
Mechanically compliant implants as a strategy to decrease foreign body reaction to nerve interfaces
42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence (Seattle, WA, April 3, 2019 - April 6, 2019)
In: Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium 2019 , , , , :
Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons
In: Cell 176 (2019), p. 56-72.e15
ISSN: 0092-8674
DOI: 10.1016/j.cell.2018.11.030 , , , , , , , , , , :
Kymobutler, a deep learning software for automated kymograph analysis
In: eLife 8 (2019), Article No.: e42288
ISSN: 2050-084X
DOI: 10.7554/eLife.42288 , , :
F-actin dynamics regulates mammalian organ growth and cell fate maintenance
In: Journal of Hepatology 71 (2019), p. 130-142
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2019.02.022 , , , , , , , , , , , , , , , , :
Niche stiffness underlies the ageing of central nervous system progenitor cells
In: Nature 573 (2019), p. 130-134
ISSN: 0028-0836
DOI: 10.1038/s41586-019-1484-9 , , , , , , , , , , , , , , , :
Rapid changes in tissue mechanics regulate cell behaviour in the developing embryonic brain
In: eLife 8 (2019), Article No.: e39356
ISSN: 2050-084X
DOI: 10.7554/eLife.39356 , , , , , :
2018
Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo
In: Nature 554 (2018), p. 523-527
ISSN: 0028-0836
DOI: 10.1038/nature25742 , , , :
Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis
In: Nature Communications 9 (2018), Article No.: 2961
ISSN: 2041-1723
DOI: 10.1038/s41467-018-05388-x , , , , , , , , , , , :
Single-molecule analysis of endogenous β-actin mRNA trafficking reveals a mechanism for compartmentalized mRNA localization in axons
In: Proceedings of the National Academy of Sciences of the United States of America 115 (2018), p. E9697-E9706
ISSN: 0027-8424
DOI: 10.1073/pnas.1806189115 , , , , , , :
2017
Laminin Levels Regulate Tissue Migration and Anterior-Posterior Polarity during Egg Morphogenesis in Drosophila
In: Cell Reports 20 (2017), p. 211-223
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2017.06.031 , , , , , , , :
Long-term imaging of cellular forces with high precision by elastic resonator interference stress microscopy
In: Nature Cell Biology 19 (2017), p. 864-872
ISSN: 1465-7392
DOI: 10.1038/ncb3561 , , , , , , , , :
The soft mechanical signature of glial scars in the central nervous system
In: Nature Communications 8 (2017), Article No.: 14787
ISSN: 2041-1723
DOI: 10.1038/ncomms14787 , , , , , , , , :
Effect of vital dyes on human corneal endothelium and elasticity of Descemet’s membrane
In: PLoS ONE 12 (2017), Article No.: e0184375
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0184375 , , , , , :
The role of cell body density in ruminant retina mechanics assessed by atomic force and Brillouin microscopy
In: Physical Biology 14 (2017), Article No.: 065006
ISSN: 1478-3967
DOI: 10.1088/1478-3975/aa6d18 , , , :
2016
Brain tissue stiffness is a sensitive marker for acidosis
In: Journal of Neuroscience Methods 271 (2016), p. 50-54
ISSN: 0165-0270
DOI: 10.1016/j.jneumeth.2016.07.002 , , , , , :
Mechanosensing is critical for axon growth in the developing brain
In: Nature Neuroscience 19 (2016), p. 1592-1598
ISSN: 1097-6256
DOI: 10.1038/nn.4394 , , , , , , , , , , , :
ECM-Regulator timp Is Required for Stem Cell Niche Organization and Cyst Production in the Drosophila Ovary
In: PLoS Genetics 12 (2016), Article No.: e1005763
ISSN: 1553-7390
DOI: 10.1371/journal.pgen.1005763 , , , , , , , :
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
In: Nature 537 (2016), p. 544-547
ISSN: 0028-0836
DOI: 10.1038/nature19353 , , , , , , , , , , , , , , , , , , , , , , , :
2015
Development of the anterior-posterior axis is a self-organizing process in the absence of maternal cues in the mouse embryo
In: Cell Research 25 (2015), p. 1368-1371
ISSN: 1001-0602
DOI: 10.1038/cr.2015.104 , , , , , , , :
Microglia mechanics: Immune activation alters traction forces and durotaxis
In: Frontiers in Cellular Neuroscience 9 (2015), p. 1-16
ISSN: 1662-5102
DOI: 10.3389/fncel.2015.00363 , , , , , , , , :
Atomic force microscopy-based force measurements on animal cells and tissues
In: Methods in Cell Biology, Academic Press Inc., 2015, p. 211-235
DOI: 10.1016/bs.mcb.2014.10.005 , , , , , , :
Force generation by molecular-motor-powered microtubule bundles; implications for neuronal polarization and growth
In: Frontiers in Cellular Neuroscience 9 (2015), Article No.: 441
ISSN: 1662-5102
DOI: 10.3389/fncel.2015.00441 , , :
CNS cell distribution and axon orientation determine local spinal cord mechanical properties
In: Biophysical Journal 108 (2015), p. 2137-2147
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2015.03.039 , , , , :
Müller glia provide essential tensile strength to the developing retina
In: The Journal of Cell Biology 210 (2015), p. 1075-1083
ISSN: 0021-9525
DOI: 10.1083/jcb.201503115 , , , , , :
Speed and sensitivity of phototransduction in Drosophila depend on degree of saturation of membrane phospholipids
In: The Journal of Neuroscience 35 (2015), p. 2731-2746
ISSN: 1529-2401
DOI: 10.1523/JNEUROSCI.1150-14.2015 , , , , , , , , :
2014
Kein Irrtum der Natur: Wie Licht durch die umgekehrte Retina von Wirbeltieren gelangt
In: Neuroforum 20 (2014), p. 296-304
ISSN: 0947-0875 , , , :
The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system
In: Biomaterials 35 (2014), p. 3919-3925
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2014.01.038 , , , , , , , :
Auxetic nuclei in embryonic stem cells exiting pluripotency
In: Nature Materials 13 (2014), p. 638-644
ISSN: 1476-1122
DOI: 10.1038/nmat3943 , , , , , , , , :
2013
The mechanical control of nervous system development
In: Development 140 (2013), p. 3069-3077
ISSN: 1477-9129
DOI: 10.1242/dev.079145 :
Mechanics in neuronal development and repair
In: Annual Review of Biomedical Engineering, 2013, p. 227-251
DOI: 10.1146/annurev-bioeng-071811-150045 , , :
2012
Photomechanical responses in Drosophila photoreceptors
In: Science 338 (2012), p. 260-263
ISSN: 0036-8075
DOI: 10.1126/science.1222376 , :
Photonic crystal light collectors in fish retina improve vision in turbid water
In: Science 336 (2012), p. 1700-1703
ISSN: 0036-8075
DOI: 10.1126/science.1218072 , , , , , , , , , , , , , , , , , , , , , :
Complex stiffness gradient substrates for studying mechanotactic cell migration
In: Advanced Materials 24 (2012), p. 6059-6064
ISSN: 0935-9648
DOI: 10.1002/adma.201202520 , , , , :
Reversible switching between superhydrophobic states on a hierarchically structured surface
In: Proceedings of the National Academy of Sciences of the United States of America 109 (2012), p. 10210-10213
ISSN: 0027-8424
DOI: 10.1073/pnas.1204328109 , , , , , , , , , :
2011
Growth cones as soft and weak force generators
In: Proceedings of the National Academy of Sciences of the United States of America 108 (2011), p. 13420-13425
ISSN: 0027-8424
DOI: 10.1073/pnas.1106145108 , , , , :
Atomic force microscopy and its contribution to understanding the development of the nervous system
In: Current Opinion in Genetics & Development 21 (2011), p. 530-537
ISSN: 0959-437X
DOI: 10.1016/j.gde.2011.07.001 :
Spatial mapping of the mechanical properties of the living retina using scanning force microscopy
In: Soft Matter 7 (2011), p. 3147-3154
ISSN: 1744-683X
DOI: 10.1039/c0sm01017k , , , , , , :
2010
Mechanical difference between white and gray matter in the rat cerebellum measured by scanning force microscopy
In: Journal of Biomechanics 43 (2010), p. 2986-2992
ISSN: 0021-9290
DOI: 10.1016/j.jbiomech.2010.07.002 , , , , , , , :
The biophysics of neuronal growth
In: Reports on Progress in Physics 73 (2010), Article No.: 094601
ISSN: 0034-4885
DOI: 10.1088/0034-4885/73/9/094601 , :
Retinal Glial (Müller) Cells: Sensing and responding to tissue stretch
In: Investigative Ophthalmology & Visual Science 51 (2010), p. 1683-1690
ISSN: 0146-0404
DOI: 10.1167/iovs.09-4159 , , , , :
Mechanosensitivity of astrocytes on optimized polyacrylamide gels analyzed by quantitative morphometry
In: Journal of Physics: Condensed Matter 22 (2010), Article No.: 194114
ISSN: 0953-8984
DOI: 10.1088/0953-8984/22/19/194114 , , , , , , :
Metastable underwater superhydrophobicity
In: Physical Review Letters 105 (2010), Article No.: 166104
ISSN: 0031-9007
DOI: 10.1103/PhysRevLett.105.166104 , , , :
Dual-beam laser traps in biology and medicine: When one beam is not enough
Optical Trapping and Optical Micromanipulation VII (, August 1, 2010 - August 5, 2010)
In: Proceedings of SPIE - The International Society for Optical Engineering 2010
DOI: 10.1117/12.862928 , , , , , , , , :
2009
Neurite branch retraction is caused by a threshold-dependent mechanical impact
In: Biophysical Journal 97 (2009), p. 1883-1890
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.07.033 , , , , , , , , , , , , :
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