Dr. Ing. Silvia Budday
Department of Mechanical Engineering
Institute of Applied Mechanics
Friedrich-Alexander-Universität Erlangen-Nürnberg
silvia.budday@fau.de
Academic Young Talent 2022
Modeling and simulation of growth in soft biomaterials, Brain mechanics across Scales
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Gala der Deutschen Wissenschaft 2022: the academic Young Talent Award
Silvia Budday, Academics Young Talent Award, 2022
VPH2022: Microstructure-informed in silico modeling of the human brain
Microstructure-informed in silico modeling of the human brain, September 8, 2022
Publications
2025
Dynamic traction force measurements of migrating immune cells in 3D matrices
(2025)
DOI: 10.1101/2022.11.16.516758 , , , , , , , , , , , , , :
2024
Accuracy meets simplicity: A constitutive model for heterogenous brain tissue
In: Journal of the Mechanical Behavior of Biomedical Materials 150 (2024), Article No.: 106271
ISSN: 1751-6161
DOI: 10.1016/j.jmbbm.2023.106271 , , , , :
A comparison of brain retraction mechanisms using finite element analysis and the effects of regionally heterogeneous material properties
In: Biomechanics and Modeling in Mechanobiology 23 (2024), p. 793-808
ISSN: 1617-7959
DOI: 10.1007/s10237-023-01806-2 , , :
Identifying composition-mechanics relations in human brain tissue based on neural-network-enhanced inverse parameter identification
In: Mathematics and Mechanics of Solids (2024)
ISSN: 1081-2865
DOI: 10.1177/10812865231206544 , , , , , , :
Using dropout based active learning and surrogate models in the inverse viscoelastic parameter identification of human brain tissue
In: Frontiers in Physiology 15 (2024), Article No.: 1321298
ISSN: 1664-042X
DOI: 10.3389/fphys.2024.1321298 , , , :
Engineering peptide-modified alginate-based bioinks with cell-adhesive properties for biofabrication
In: RSC Advances 14 (2024), p. 13769-13786
ISSN: 2046-2069
DOI: 10.1039/d3ra08394b , , , , , , , , :
Breast Tumor Cell Survival and Morphology in a Brain-like Extracellular Matrix Depends on Matrix Composition and Mechanical Properties
In: Advanced Biology 8 (2024), Article No.: 2400184
ISSN: 2701-0198
DOI: 10.1002/adbi.202400184 , , , , , , , , , , , , , , , :
2023
Predicting the hyperelastic properties of alginate-gelatin hydrogels and 3D bioprinted mesostructures
In: Scientific Reports 13 (2023), Article No.: 21858
ISSN: 2045-2322
DOI: 10.1038/s41598-023-48711-3 , :
Multilayer 3D bioprinting and complex mechanical properties of alginate-gelatin mesostructures
In: Scientific Reports 13 (2023), p. 11253-
ISSN: 2045-2322
DOI: 10.1038/s41598-023-38323-2 , , , :
Simulating the mechanical stimulation of cells on a porous hydrogel scaffold using an FSI model to predict cell differentiation
In: Frontiers in Bioengineering and Biotechnology 11 (2023), Article No.: 1249867
ISSN: 2296-4185
DOI: 10.3389/fbioe.2023.1249867 , , , :
Mechanical behavior of the hippocampus and corpus callosum: An attempt to reconcile ex vivo with in vivo and micro with macro properties
In: Journal of the Mechanical Behavior of Biomedical Materials 138 (2023), Article No.: 105613
ISSN: 1751-6161
DOI: 10.1016/j.jmbbm.2022.105613 , , , , , , , , , , , , , :
Exploring human brain mechanics by combining experiments, modeling, and simulation
In: Brain Multiphysics 5 (2023), Article No.: 100076
ISSN: 2666-5220
DOI: 10.1016/j.brain.2023.100076 :
Fiber alignment in 3D collagen networks as a biophysical marker for cell contractility
In: Matrix Biology 124 (2023), p. 39-48
ISSN: 0945-053X
DOI: 10.1016/j.matbio.2023.11.004 , , , , , , , , , , , , , , , , :
Reinforcing Tissue-Engineered Cartilage: Nanofibrillated Cellulose Enhances Mechanical Properties of Alginate Dialdehyde–Gelatin Hydrogel
In: Advanced Engineering Materials (2023)
ISSN: 1438-1656
DOI: 10.1002/adem.202300641 , , , , , :
Automated discovery of interpretable hyperelastic material models for human brain tissue with EUCLID
In: Journal of the Mechanics and Physics of Solids 180 (2023), Article No.: 105404
ISSN: 0022-5096
DOI: 10.1016/j.jmps.2023.105404 , , , , , , , :
On the importance of using region-dependent material parameters for full-scale human brain simulations
In: European Journal of Mechanics A-Solids 99 (2023), Article No.: 104910
ISSN: 0997-7538
DOI: 10.1016/j.euromechsol.2023.104910 , , , :
Inverse identification of region-specific hyperelastic material parameters for human brain tissue
In: Biomechanics and modeling in mechanobiology (2023)
ISSN: 1617-7940
DOI: 10.1007/s10237-023-01739-w , , , , , :
Inverse identification of region-specific hyperelastic material parameters for human brain tissue
In: Biomechanics and Modeling in Mechanobiology (2023)
ISSN: 1617-7959
DOI: 10.1007/s10237-023-01739-w , , , , , :
Poro-viscoelastic material parameter identification of brain tissue-mimicking hydrogels
In: Frontiers in Bioengineering and Biotechnology 11 (2023), Article No.: 1143304
ISSN: 2296-4185
DOI: 10.3389/fbioe.2023.1143304 , , , , , , , , :
Mechanisms of mechanical load transfer through brain tissue
In: Scientific Reports 13 (2023), Article No.: 8703
ISSN: 2045-2322
DOI: 10.1038/s41598-023-35768-3 , , :
Modeling the finite viscoelasticity of human brain tissue based on microstructural information
In: Proceedings in Applied Mathematics and Mechanics (2023)
ISSN: 1617-7061
DOI: 10.1002/pamm.202300234 , , , , :
Dried Vegetables as Potential Clean-Label Phosphate Substitutes in Cooked Sausage Meat
In: Foods 12 (2023), Article No.: 1960
ISSN: 2304-8158
DOI: 10.3390/foods12101960 , , , , :
Time-dependent hyper-viscoelastic parameter identification of human articular cartilage and substitute materials
In: Journal of the Mechanical Behavior of Biomedical Materials 138 (2023), Article No.: 105618
ISSN: 1751-6161
DOI: 10.1016/j.jmbbm.2022.105618 , , , , , :
Exploring the role of the outer subventricular zone during cortical folding through a physics-based model
In: eLife 12 (2023)
ISSN: 2050-084X
DOI: 10.7554/eLife.82925 , , :
Multifield computational model for human brain development: Explicit numerical stabilization
In: Proceedings in Applied Mathematics and Mechanics (2023)
ISSN: 1617-7061
DOI: 10.1002/pamm.202300288 , , :
2022
Tissue-Scale Biomechanical Testing of Brain Tissue for the Calibration of Nonlinear Material Models
In: Current Protocols 2 (2022), p. e381-
ISSN: 2691-1299
DOI: 10.1002/cpz1.381 , , , , :
Finite element modeling of traumatic brain injury: Areas of future interest
In: Current Opinion in Biomedical Engineering 24 (2022), Article No.: 100421
ISSN: 2468-4511
DOI: 10.1016/j.cobme.2022.100421 , :
Reinforced Hyaluronic Acid-Based Matrices Promote 3D Neuronal Network Formation
In: Advanced Healthcare Materials (2022)
ISSN: 2192-2640
DOI: 10.1002/adhm.202201826 , , , , , , , , , , , , , , :
Oxidized Hyaluronic Acid-Gelatin-Based Hydrogels for Tissue Engineering and Soft Tissue Mimicking
In: Tissue Engineering - Part C: Methods (2022)
ISSN: 1937-3384
DOI: 10.1089/ten.tec.2022.0004 , , , , , , , :
Biomechanical analysis of the cervical spine segment as a method for studying the functional and dynamic anatomy of the human neck
In: Annals of Anatomy-Anatomischer Anzeiger 240 (2022), Article No.: 151856
ISSN: 0940-9602
DOI: 10.1016/j.aanat.2021.151856 , , , , , , , , , , , , :
Hyperelastic parameter identification of human articular cartilage and substitute materials
In: Journal of the Mechanical Behavior of Biomedical Materials 133 (2022)
ISSN: 1751-6161
DOI: 10.1016/j.jmbbm.2022.105292 , , , , , , , :
2021
Neocortical development and epilepsy: insights from focal cortical dysplasia and brain tumours
In: Lancet Neurology 20 (2021), p. 943-955
ISSN: 1474-4422
DOI: 10.1016/S1474-4422(21)00265-9 , , , , , :
Editorial: Advances in Brain Mechanics
In: Frontiers in Mechanical Engineering 7 (2021)
ISSN: 2297-3079
DOI: 10.3389/fmech.2021.803151 , , :
Mechanical properties of cell- and microgel bead-laden oxidized alginate-gelatin hydrogels
In: Biomaterials Science (2021), Article No.: d0bm02117b
ISSN: 2047-4830
DOI: 10.1039/D0BM02117B
URL: https://pubs.rsc.org/en/content/articlelanding/2021/bm/d0bm02117b , , , , , , , , , :
Spinal Cord Neuronal Network Formation in a 3D Printed Reinforced Matrix—A Model System to Study Disease Mechanisms
In: Advanced Healthcare Materials (2021)
ISSN: 2192-2640
DOI: 10.1002/adhm.202100830
URL: https://onlinelibrary.wiley.com/doi/10.1002/adhm.202100830?af=R , , , , , , :
Physical aspects of cortical folding
In: Soft Matter (2021)
ISSN: 1744-683X
DOI: 10.1039/d0sm02209h , , :
Poro-Viscoelastic Effects During Biomechanical Testing of Human Brain Tissue
In: Frontiers in Mechanical Engineering 7 (2021), Article No.: 708350
ISSN: 2297-3079
DOI: 10.3389/fmech.2021.708350 , , , , , , :
Unraveling the Local Relation Between Tissue Composition and Human Brain Mechanics Through Machine Learning
In: Frontiers in Bioengineering and Biotechnology 9 (2021)
ISSN: 2296-4185
DOI: 10.3389/fbioe.2021.704738 , , , , , , , :
Spatiotemporal modeling of first and second wave outbreak dynamics of COVID‐19 in Germany
In: Biomechanics and Modeling in Mechanobiology (2021)
ISSN: 1617-7959
DOI: 10.1007/s10237-021-01520-x , , , , , , , , :
Insights into the Microstructural Origin of Brain Viscoelasticity
In: Journal of Elasticity 145 (2021), p. 99-116
ISSN: 0374-3535
DOI: 10.1007/s10659-021-09814-y
URL: https://link.springer.com/article/10.1007/s10659-021-09814-y , , , :
A two-field computational model couples cellular brain development with cortical folding
In: Brain Multiphysics 2 (2021), p. 100025
ISSN: 2666-5220
DOI: 10.1016/j.brain.2021.100025 , , , , :
Exploring the interplay between cellular development and mechanics in the developing human brain
In: Proceedings in Applied Mathematics and Mechanics 21 (2021), Article No.: e202100104
ISSN: 1617-7061
DOI: 10.1002/pamm.202100104 , , , , :
2020
Modeling the life cycle of the human brain
In: Current Opinion in Biomedical Engineering (2020)
ISSN: 2468-4511
DOI: 10.1016/j.cobme.2019.12.009
URL: https://www.sciencedirect.com/science/article/pii/S2468451119300832?via=ihub , :
Fifty Shades of Brain: A Review on the Mechanical Testing and Modeling of Brain Tissue
In: Archives of Computational Methods in Engineering 27 (2020), p. 1187–1230
ISSN: 1134-3060
DOI: 10.1007/s11831-019-09352-w
URL: https://link.springer.com/article/10.1007/s11831-019-09352-w , , , , :
Towards microstructure-informed material models for human brain tissue
In: Acta Biomaterialia 104 (2020), p. 53-65
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2019.12.030
URL: https://www.sciencedirect.com/science/article/pii/S1742706119308682?via=ihub , , , , , , , , , , :
Modeling the porous and viscous responses of human brain tissue behavior
In: Computer Methods in Applied Mechanics and Engineering 369 (2020), Article No.: 113128
ISSN: 0045-7825
DOI: 10.1016/j.cma.2020.113128
URL: https://www.sciencedirect.com/science/article/pii/S0045782520303133 , , , , :
Alginate-based hydrogels show the same complex mechanical behavior as brain tissue
In: Journal of the Mechanical Behavior of Biomedical Materials 111 (2020), Article No.: 103979
ISSN: 1751-6161
DOI: 10.1016/j.jmbbm.2020.103979
URL: https://www.sciencedirect.com/science/article/abs/pii/S1751616120305312 , , , , :
Folding drives cortical thickness variations
In: European Physical Journal - Special Topics 229 (2020), p. 2757-2778
ISSN: 1951-6355
DOI: 10.1140/epjst/e2020-000001-6 , , , , , :
Memory-based meso-scale modeling of Covid-19
In: Computational Mechanics (2020)
ISSN: 0178-7675
DOI: 10.1007/s00466-020-01883-5 , , , , , , , :
Complex mechanical behavior of human articular cartilage and hydrogels for cartilage repair
In: Acta Biomaterialia (2020)
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2020.10.025
URL: https://www.sciencedirect.com/science/article/pii/S1742706120306140 , , , , , , , , , :
2019
Challenges and perspectives in brain tissue testing and modeling
In: Proceedings in Applied Mathematics and Mechanics accepted (2019)
ISSN: 1617-7061
DOI: 10.1002/pamm.201900269 , , , :
2018
The origin of compression influences geometric instabilities in bilayers
In: Proceedings of the Royal Society A-Mathematical Physical and Engineering Sciences (2018)
ISSN: 1364-5021
DOI: 10.1098/rspa.2018.0267 , , :
The Role of Mechanics during Brain Development (Dissertation, 2018)
URL: https://opus4.kobv.de/opus4-fau/frontdoor/index/index/year/2018/docId/9298 :
Region‐ and loading‐specific finite viscoelasticity of human brain tissue
In: Proceedings in Applied Mathematics and Mechanics 18 (2018), Article No.: e201800169
ISSN: 1617-7061
DOI: 10.1002/pamm.201800169 , , , , , :
Symmetry Breaking in Wrinkling Patterns: Gyri Are Universally Thicker than Sulci
In: Physical Review Letters 121 (2018), Article No.: 228002
ISSN: 0031-9007
DOI: 10.1103/PhysRevLett.121.228002 , , , :
2017
Wrinkling instabilities in soft bi-layered systems
In: Philosophical Transactions of the Royal Society A-Mathematical Physical and Engineering Sciences 375 (2017)
ISSN: 1364-503X
DOI: 10.1098/rsta.2016.0163 , , , , :
Mechanical characterization of human brain tissue
In: Acta Biomaterialia 48 (2017), p. 319–340
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2016.10.036 , , , , , , , , , , :
Rheological characterization of human brain tissue
In: Acta Biomaterialia (2017)
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2017.06.024 , , , , , :
Viscoelastic parameter identification of human brain tissue
In: Journal of the Mechanical Behavior of Biomedical Materials 74 (2017), p. 463-476
ISSN: 1751-6161
DOI: 10.1016/j.jmbbm.2017.07.014 , , , , :
On the influence of inhomogeneous stiffness and growth on mechanical instabilities in the developing brain
In: International Journal of Solids and Structures (2017)
ISSN: 0020-7683
DOI: 10.1016/j.ijsolstr.2017.08.010 , :
A family of hyperelastic models for human brain tissue
In: Journal of the Mechanics and Physics of Solids 106 (2017), p. 60-79
ISSN: 0022-5096
DOI: 10.1016/j.jmps.2017.05.015 , , , , :
The mechanical importance of myelination in the central nervous system
In: Journal of the Mechanical Behavior of Biomedical Materials (2017)
ISSN: 1751-6161
DOI: 10.1016/j.jmbbm.2017.04.017 , , , , :
2016
Brain stiffness increases with myelin content
In: Acta Biomaterialia (2016), p. 265–272
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2016.07.040 , , , , , :
2015
Period-doubling and period-tripling in growing bilayered systems
In: Philosophical Magazine - (2015), p. 1-17
ISSN: 1478-6443
DOI: 10.1080/14786435.2015.1014443 , , :
Mechanical properties of gray and white matter brain tissue by indentation
In: Journal of the Mechanical Behavior of Biomedical Materials (2015), p. 318-330
ISSN: 1751-6161
DOI: 10.1016/j.jmbbm.2015.02.024 , , , , , , :
Size and curvature regulate pattern selection in the mammalian brain
In: Extreme Mechanics Letters 4 (2015), p. 193-198
ISSN: 2352-4316
DOI: 10.1016/j.eml.2015.07.004 , , , :
Physical biology of human brain development
In: Frontiers in Cellular Neuroscience 9 (2015), p. 1-13
ISSN: 1662-5102
DOI: 10.3389/fncel.2015.00257 , , :
Secondary instabilities modulate cortical complexity in the mammalian brain
In: Philosophical Magazine 95 (2015), p. 3244–3256
ISSN: 1478-6435
DOI: 10.1080/14786435.2015.1024184 , , :
Primary and secondary instabilities in soft bilayered systems
GAMM Jahrestagung (Lecce)
In: PAMM, Weinheim: 2015
DOI: 10.1002/pamm.201510131 , , , :
Chapter two-neuromechanics: From neurons to brain
In: Advances in Applied Mechanics 48 (2015), p. 79--139
ISSN: 0065-2156
DOI: 10.1016/bs.aams.2015.10.002 , , :
2014
A mechanical model predicts morphological abnormalities in the developing human brain
In: Scientific Reports 4 (2014)
ISSN: 2045-2322
DOI: 10.1038/srep05644 , , :
A mechanical approach to explain cortical folding phenomena in healthy and diseased brains
GAMM 2014 (Erlangen, Germany, March 10, 2014 - March 14, 2014)
In: PAMM, Erlangen, Germany: 2014
DOI: 10.1002/pamm.201410038 , , :
The role of mechanics during brain development
In: Journal of the Mechanics and Physics of Solids 72 (2014), p. 75-92
ISSN: 0022-5096
DOI: 10.1016/j.jmps.2014.07.010 , , :
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