Silvia Budday

2025

• Böhringer D., Cóndor M., Bischof L., Czerwinski T., Gampl N., Ngo P., Bauer A., Bosch-Voskens C., Lopez Posadas R., Franze K., Budday S., Mark C., Fabry B., Gerum R.:
  Dynamic traction force measurements of migrating immune cells in 3D matrices
  (2025)
  DOI: 10.1101/2022.11.16.516758

2024

• Filla N., Hou J., Liu T., Budday S., Wang X.:
  Accuracy meets simplicity: A constitutive model for heterogenous brain tissue
  In: Journal of the Mechanical Behavior of Biomedical Materials 150 (2024), Article No.: 106271
  ISSN: 1751-6161
  DOI: 10.1016/j.jmbbm.2023.106271
• Hinrichsen J., Feiler L., Reiter N., Bräuer L., Schicht M., Paulsen F., Budday S.:
  Identifying composition-mechanics relations in human brain tissue based on neural-network-enhanced inverse parameter identification
  In: Mathematics and Mechanics of Solids (2024)
  ISSN: 1081-2865
  DOI: 10.1177/10812865231206544
• Hinrichsen J., Ferlay C., Reiter N., Budday S.:
  Using dropout based active learning and surrogate models in the inverse viscoelastic parameter identification of human brain tissue
  In: Frontiers in Physiology 15 (2024), Article No.: 1321298
  ISSN: 1664-042X
  DOI: 10.3389/fphys.2024.1321298
• Karakaya E., Gleichauf L., Schöbel L., Hassan A., Ahmadi Soufivand A., Tessmar J., Budday S., Boccaccini AR., Detsch R.:
  Engineering peptide-modified alginate-based bioinks with cell-adhesive properties for biofabrication
  In: RSC Advances 14 (2024), p. 13769-13786
  ISSN: 2046-2069
  DOI: 10.1039/d3ra08394b

2023

• Ahmadi Soufivand A., Budday S.:
  Predicting the hyperelastic properties of alginate-gelatin hydrogels and 3D bioprinted mesostructures
  In: Scientific Reports 13 (2023), Article No.: 21858
  ISSN: 2045-2322
  DOI: 10.1038/s41598-023-48711-3
• Ahmadi Soufivand A., Faber J., Hinrichsen J., Budday S.:
  Multilayer 3D bioprinting and complex mechanical properties of alginate-gelatin mesostructures
  In: Scientific Reports 13 (2023), p. 11253-
  ISSN: 2045-2322
  DOI: 10.1038/s41598-023-38323-2
• Azizi P., Drobek C., Budday S., Seitz H.:
  Simulating the mechanical stimulation of cells on a porous hydrogel scaffold using an FSI model to predict cell differentiation
  In: Frontiers in Bioengineering and Biotechnology 11 (2023), Article No.: 1249867
  ISSN: 2296-4185
  DOI: 10.3389/fbioe.2023.1249867
• Bertalan G., Becker J., Tzschätzsch H., Morr A., Herthum H., Shahryari M., Greenhalgh RD., Guo J., Schröder L., Alzheimer C., Budday S., Franze K., Braun J., Sack I.:
  Mechanical behavior of the hippocampus and corpus callosum: An attempt to reconcile ex vivo with in vivo and micro with macro properties
  In: Journal of the Mechanical Behavior of Biomedical Materials 138 (2023), Article No.: 105613
  ISSN: 1751-6161
  DOI: 10.1016/j.jmbbm.2022.105613
• Budday S.:
  Exploring human brain mechanics by combining experiments, modeling, and simulation
  In: Brain Multiphysics 5 (2023), Article No.: 100076
  ISSN: 2666-5220
  DOI: 10.1016/j.brain.2023.100076
• Böhringer D., Bauer A., Moravec I., Bischof L., Kah DE., Mark C., Grundy TJ., Görlach E., O'Neill GM., Budday S., Strissel P., Strick R., Malandrino A., Gerum R., Mak M., Rausch M., Fabry B.:
  Fiber alignment in 3D collagen networks as a biophysical marker for cell contractility
  In: Matrix Biology 124 (2023), p. 39-48
  ISSN: 0945-053X
  DOI: 10.1016/j.matbio.2023.11.004
• Chayanun S., Ahmadi Soufivand A., Faber J., Budday S., Lohwongwatana B., Boccaccini AR.:
  Reinforcing Tissue-Engineered Cartilage: Nanofibrillated Cellulose Enhances Mechanical Properties of Alginate Dialdehyde–Gelatin Hydrogel
  In: Advanced Engineering Materials (2023)
  ISSN: 1438-1656
  DOI: 10.1002/adem.202300641
• Flaschel M., Yu H., Reiter N., Hinrichsen J., Budday S., Steinmann P., Kumar S., De Lorenzis L.:
  Automated discovery of interpretable hyperelastic material models for human brain tissue with EUCLID
  In: Journal of the Mechanics and Physics of Solids 180 (2023), Article No.: 105404
  ISSN: 0022-5096
  DOI: 10.1016/j.jmps.2023.105404
• Griffiths E., Hinrichsen J., Reiter N., Budday S.:
  On the importance of using region-dependent material parameters for full-scale human brain simulations
  In: European Journal of Mechanics A-Solids 99 (2023), Article No.: 104910
  ISSN: 0997-7538
  DOI: 10.1016/j.euromechsol.2023.104910
• Hinrichsen J., Reiter N., Bräuer L., Paulsen F., Käßmair S., Budday S.:
  Inverse identification of region-specific hyperelastic material parameters for human brain tissue
  In: Biomechanics and modeling in mechanobiology (2023)
  ISSN: 1617-7940
  DOI: 10.1007/s10237-023-01739-w
• Hinrichsen J., Reiter N., Bräuer L., Paulsen F., Käßmair S., Budday S.:
  Inverse identification of region-specific hyperelastic material parameters for human brain tissue
  In: Biomechanics and Modeling in Mechanobiology (2023)
  ISSN: 1617-7959
  DOI: 10.1007/s10237-023-01739-w
• Kainz MP., Greiner A., Hinrichsen J., Kolb D., Comellas E., Steinmann P., Budday S., Terzano M., Holzapfel GA.:
  Poro-viscoelastic material parameter identification of brain tissue-mimicking hydrogels
  In: Frontiers in Bioengineering and Biotechnology 11 (2023), Article No.: 1143304
  ISSN: 2296-4185
  DOI: 10.3389/fbioe.2023.1143304
• Reiter N., Paulsen F., Budday S.:
  Mechanisms of mechanical load transfer through brain tissue
  In: Scientific Reports 13 (2023), Article No.: 8703
  ISSN: 2045-2322
  DOI: 10.1038/s41598-023-35768-3
• Reiter N., Schäfer AM., Auer S., Paulsen F., Budday S.:
  Modeling the finite viscoelasticity of human brain tissue based on microstructural information
  In: Proceedings in Applied Mathematics and Mechanics (2023)
  ISSN: 1617-7061
  DOI: 10.1002/pamm.202300234
• Weigel I., Nistler S., Pichner R., Budday S., Gensberger-Reigl S.:
  Dried Vegetables as Potential Clean-Label Phosphate Substitutes in Cooked Sausage Meat
  In: Foods 12 (2023), Article No.: 1960
  ISSN: 2304-8158
  DOI: 10.3390/foods12101960
• Weizel A., Distler T., Detsch R., Boccaccini AR., Seitz H., Budday S.:
  Time-dependent hyper-viscoelastic parameter identification of human articular cartilage and substitute materials
  In: Journal of the Mechanical Behavior of Biomedical Materials 138 (2023), Article No.: 105618
  ISSN: 1751-6161
  DOI: 10.1016/j.jmbbm.2022.105618
• Zarzor MS., Blümcke I., Budday S.:
  Exploring the role of the outer subventricular zone during cortical folding through a physics-based model
  In: eLife 12 (2023)
  ISSN: 2050-084X
  DOI: 10.7554/eLife.82925
• Zarzor MS., Steinmann P., Budday S.:
  Multifield computational model for human brain development: Explicit numerical stabilization
  In: Proceedings in Applied Mathematics and Mechanics (2023)
  ISSN: 1617-7061
  DOI: 10.1002/pamm.202300288

2022

• Faber J., Hinrichsen J., Greiner A., Reiter N., Budday S.:
  Tissue-Scale Biomechanical Testing of Brain Tissue for the Calibration of Nonlinear Material Models
  In: Current Protocols 2 (2022), p. e381-
  ISSN: 2691-1299
  DOI: 10.1002/cpz1.381
• Griffiths E., Budday S.:
  Finite element modeling of traumatic brain injury: Areas of future interest
  In: Current Opinion in Biomedical Engineering 24 (2022), Article No.: 100421
  ISSN: 2468-4511
  DOI: 10.1016/j.cobme.2022.100421
• Janzen D., Bakirci E., Faber J., Mier MA., Hauptstein J., Pal A., Forster L., Hazur J., Boccaccini AR., Detsch R., Tessmar J., Budday S., Blunk T., Dalton PD., Villmann C.:
  Reinforced Hyaluronic Acid-Based Matrices Promote 3D Neuronal Network Formation
  In: Advanced Healthcare Materials (2022)
  ISSN: 2192-2640
  DOI: 10.1002/adhm.202201826
• Kuth S., Karakaya E., Reiter N., Schmidt LP., Paulsen F., Tessmar J., Budday S., Boccaccini AR.:
  Oxidized Hyaluronic Acid-Gelatin-Based Hydrogels for Tissue Engineering and Soft Tissue Mimicking
  In: Tissue Engineering - Part C: Methods (2022)
  ISSN: 1937-3384
  DOI: 10.1089/ten.tec.2022.0004
• Ovsepyan AL., Smirnov AA., Pustozerov EA., Mokhov DE., Mokhova ES., Trunin EM., Dydykin SS., Vasil'Ev YL., Yakovlev EV., Budday S., Paulsen F., Zhivolupov SA., Starchik DA.:
  Biomechanical analysis of the cervical spine segment as a method for studying the functional and dynamic anatomy of the human neck
  In: Annals of Anatomy-Anatomischer Anzeiger 240 (2022), Article No.: 151856
  ISSN: 0940-9602
  DOI: 10.1016/j.aanat.2021.151856
• Weizel A., Distler T., Detsch R., Boccaccini AR., Paulsen F., Seitz H., Budday S., Bräuer L.:
  Hyperelastic parameter identification of human articular cartilage and substitute materials
  In: Journal of the Mechanical Behavior of Biomedical Materials 133 (2022)
  ISSN: 1751-6161
  DOI: 10.1016/j.jmbbm.2022.105292

2021

• Blümcke I., Budday S., Poduri A., Lal D., Kobow K., Baulac S.:
  Neocortical development and epilepsy: insights from focal cortical dysplasia and brain tumours
  In: Lancet Neurology 20 (2021), p. 943-955
  ISSN: 1474-4422
  DOI: 10.1016/S1474-4422(21)00265-9
• Budday S., Bayly PV., Holzapfel GA.:
  Editorial: Advances in Brain Mechanics
  In: Frontiers in Mechanical Engineering 7 (2021)
  ISSN: 2297-3079
  DOI: 10.3389/fmech.2021.803151
• Distler T., Kretzschmar L., Schneidereit D., Girardo S., Goswami R., Friedrich O., Detsch R., Guck J., Boccaccini AR., Budday S.:
  Mechanical properties of cell- and microgel bead-laden oxidized alginate-gelatin hydrogels
  In: Biomaterials Science (2021), Article No.: d0bm02117b
  ISSN: 2047-4830
  DOI: 10.1039/D0BM02117B
  URL: https://pubs.rsc.org/en/content/articlelanding/2021/bm/d0bm02117b
• Fischhaber N., Faber J., Bakirci E., Dalton PD., Budday S., Villmann C., Schaefer N.:
  Spinal Cord Neuronal Network Formation in a 3D Printed Reinforced Matrix—A Model System to Study Disease Mechanisms
  In: Advanced Healthcare Materials (2021)
  ISSN: 2192-2640
  DOI: 10.1002/adhm.202100830
  URL: https://onlinelibrary.wiley.com/doi/10.1002/adhm.202100830?af=R
• Greiner A., Käßmair S., Budday S.:
  Physical aspects of cortical folding
  In: Soft Matter (2021)
  ISSN: 1744-683X
  DOI: 10.1039/d0sm02209h
• Greiner A., Reiter N., Paulsen F., Holzapfel GA., Steinmann P., Comellas Sanfeliu E., Budday S.:
  Poro-Viscoelastic Effects During Biomechanical Testing of Human Brain Tissue
  In: Frontiers in Mechanical Engineering 7 (2021), Article No.: 708350
  ISSN: 2297-3079
  DOI: 10.3389/fmech.2021.708350
• Linka K., Reiter N., Würges J., Schicht M., Cyron CJ., Paulsen F., Budday S., Bräuer L.:
  Unraveling the Local Relation Between Tissue Composition and Human Brain Mechanics Through Machine Learning
  In: Frontiers in Bioengineering and Biotechnology 9 (2021)
  ISSN: 2296-4185
  DOI: 10.3389/fbioe.2021.704738
• Lippold D., Kergaßner A., Burkhardt C., Kergaßner M., Loos J., Nistler S., Steinmann P., Budday D., Budday S.:
  Spatiotemporal modeling of first and second wave outbreak dynamics of COVID‐19 in Germany
  In: Biomechanics and Modeling in Mechanobiology (2021)
  ISSN: 1617-7959
  DOI: 10.1007/s10237-021-01520-x
• Reiter N., Roy B., Paulsen F., Budday S.:
  Insights into the Microstructural Origin of Brain Viscoelasticity
  In: Journal of Elasticity 145 (2021), p. 99-116
  ISSN: 0374-3535
  DOI: 10.1007/s10659-021-09814-y
  URL: https://link.springer.com/article/10.1007/s10659-021-09814-y
• Zarzor MS., Käßmair S., Steinmann P., Blümcke I., Budday S.:
  A two-field computational model couples cellular brain development with cortical folding
  In: Brain Multiphysics 2 (2021), p. 100025
  ISSN: 2666-5220
  DOI: 10.1016/j.brain.2021.100025
• Zarzor MS., Käßmair S., Steinmann P., Blümcke I., Budday S.:
  Exploring the interplay between cellular development and mechanics in the developing human brain
  In: Proceedings in Applied Mathematics and Mechanics 21 (2021), Article No.: e202100104
  ISSN: 1617-7061
  DOI: 10.1002/pamm.202100104

2020

• Budday S., Kuhl E.:
  Modeling the life cycle of the human brain
  In: Current Opinion in Biomedical Engineering (2020)
  ISSN: 2468-4511
  DOI: 10.1016/j.cobme.2019.12.009
  URL: https://www.sciencedirect.com/science/article/pii/S2468451119300832?via=ihub
• Budday S., Ovaert T., Holzapfel GA., Steinmann P., Kuhl E.:
  Fifty Shades of Brain: A Review on the Mechanical Testing and Modeling of Brain Tissue
  In: Archives of Computational Methods in Engineering 27 (2020), p. 1187–1230
  ISSN: 1134-3060
  DOI: 10.1007/s11831-019-09352-w
  URL: https://link.springer.com/article/10.1007/s11831-019-09352-w
• Budday S., Sarem M., Starck L., Sommer G., Pfefferle J., Phunchago N., Kuhl E., Paulsen F., Steinmann P., Shastri VP., Holzapfel GA.:
  Towards microstructure-informed material models for human brain tissue
  In: Acta Biomaterialia 104 (2020), p. 53-65
  ISSN: 1742-7061
  DOI: 10.1016/j.actbio.2019.12.030
  URL: https://www.sciencedirect.com/science/article/pii/S1742706119308682?via=ihub
• Comellas Sanfeliu E., Budday S., Pelteret JP., Holzapfel GA., Steinmann P.:
  Modeling the porous and viscous responses of human brain tissue behavior
  In: Computer Methods in Applied Mechanics and Engineering 369 (2020), Article No.: 113128
  ISSN: 0045-7825
  DOI: 10.1016/j.cma.2020.113128
  URL: https://www.sciencedirect.com/science/article/pii/S0045782520303133
• Distler T., Schaller E., Steinmann P., Boccaccini AR., Budday S.:
  Alginate-based hydrogels show the same complex mechanical behavior as brain tissue
  In: Journal of the Mechanical Behavior of Biomedical Materials 111 (2020), Article No.: 103979
  ISSN: 1751-6161
  DOI: 10.1016/j.jmbbm.2020.103979
  URL: https://www.sciencedirect.com/science/article/abs/pii/S1751616120305312
• Holland MA., Budday S., Li G., Shen D., Goriely A., Kuhl E.:
  Folding drives cortical thickness variations
  In: European Physical Journal - Special Topics 229 (2020), p. 2757-2778
  ISSN: 1951-6355
  DOI: 10.1140/epjst/e2020-000001-6
• Kergaßner A., Burkhardt C., Lippold D., Kergaßner M., Pflug L., Budday D., Steinmann P., Budday S.:
  Memory-based meso-scale modeling of Covid-19
  In: Computational Mechanics (2020)
  ISSN: 0178-7675
  DOI: 10.1007/s00466-020-01883-5
• Weizel A., Distler T., Schneidereit D., Friedrich O., Bräuer L., Paulsen F., Detsch R., Boccaccini AR., Budday S., Seitz H.:
  Complex mechanical behavior of human articular cartilage and hydrogels for cartilage repair
  In: Acta Biomaterialia (2020)
  ISSN: 1742-7061
  DOI: 10.1016/j.actbio.2020.10.025
  URL: https://www.sciencedirect.com/science/article/pii/S1742706120306140

2019

• Budday S., Holzapfel GA., Steinmann P., Kuhl E.:
  Challenges and perspectives in brain tissue testing and modeling
  In: Proceedings in Applied Mathematics and Mechanics accepted (2019)
  ISSN: 1617-7061
  DOI: 10.1002/pamm.201900269

2018

• Andres S., Steinmann P., Budday S.:
  The origin of compression influences geometric instabilities in bilayers
  In: Proceedings of the Royal Society A-Mathematical Physical and Engineering Sciences (2018)
  ISSN: 1364-5021
  DOI: 10.1098/rspa.2018.0267
• Budday S.:
  The Role of Mechanics during Brain Development (Dissertation, 2018)
  URL: https://opus4.kobv.de/opus4-fau/frontdoor/index/index/year/2018/docId/9298
• Budday S., Sommer G., Paulsen F., Holzapfel GA., Steinmann P., Kuhl E.:
  Region‐ and loading‐specific finite viscoelasticity of human brain tissue
  In: Proceedings in Applied Mathematics and Mechanics 18 (2018), Article No.: e201800169
  ISSN: 1617-7061
  DOI: 10.1002/pamm.201800169
• Holland M., Goriely A., Budday S., Kuhl E.:
  Symmetry Breaking in Wrinkling Patterns: Gyri Are Universally Thicker than Sulci
  In: Physical Review Letters 121 (2018), Article No.: 228002
  ISSN: 0031-9007
  DOI: 10.1103/PhysRevLett.121.228002

2017

• Budday S., Andres S., Walter B., Steinmann P., Kuhl E.:
  Wrinkling instabilities in soft bi-layered systems
  In: Philosophical Transactions of the Royal Society A-Mathematical Physical and Engineering Sciences 375 (2017)
  ISSN: 1364-503X
  DOI: 10.1098/rsta.2016.0163
• Budday S., Sommer G., Birkl C., Langkammer C., Haybaeck J., Kohnert J., Bauer M., Paulsen F., Steinmann P., Kuhl E., Holzapfel GA.:
  Mechanical characterization of human brain tissue
  In: Acta Biomaterialia 48 (2017), p. 319–340
  ISSN: 1742-7061
  DOI: 10.1016/j.actbio.2016.10.036
• Budday S., Sommer G., Haybaeck J., Steinmann P., Holzapfel GA., Kuhl E.:
  Rheological characterization of human brain tissue
  In: Acta Biomaterialia (2017)
  ISSN: 1742-7061
  DOI: 10.1016/j.actbio.2017.06.024
• Budday S., Sommer G., Holzapfel GA., Steinmann P., Kuhl E.:
  Viscoelastic parameter identification of human brain tissue
  In: Journal of the Mechanical Behavior of Biomedical Materials 74 (2017), p. 463-476
  ISSN: 1751-6161
  DOI: 10.1016/j.jmbbm.2017.07.014
• Budday S., Steinmann P.:
  On the influence of inhomogeneous stiffness and growth on mechanical instabilities in the developing brain
  In: International Journal of Solids and Structures (2017)
  ISSN: 0020-7683
  DOI: 10.1016/j.ijsolstr.2017.08.010
• Mihai LA., Budday S., Holzapfel GA., Kuhl E., Goriely A.:
  A family of hyperelastic models for human brain tissue
  In: Journal of the Mechanics and Physics of Solids 106 (2017), p. 60-79
  ISSN: 0022-5096
  DOI: 10.1016/j.jmps.2017.05.015
• Weickenmeier J., de Rooij R., Budday S., Ovaert T., Kuhl E.:
  The mechanical importance of myelination in the central nervous system
  In: Journal of the Mechanical Behavior of Biomedical Materials (2017)
  ISSN: 1751-6161
  DOI: 10.1016/j.jmbbm.2017.04.017

2016

• Weickenmeier J., de Rooij R., Budday S., Steinmann P., Ovaert T., Kuhl E.:
  Brain stiffness increases with myelin content
  In: Acta Biomaterialia (2016), p. 265–272
  ISSN: 1742-7061
  DOI: 10.1016/j.actbio.2016.07.040

2015

• Budday S., Kuhl E., Hutchinson JW.:
  Period-doubling and period-tripling in growing bilayered systems
  In: Philosophical Magazine - (2015), p. 1-17
  ISSN: 1478-6443
  DOI: 10.1080/14786435.2015.1014443
• Budday S., Nay R., de Rooij R., Steinmann P., Wyrobek T., Ovaert T., Kuhl E.:
  Mechanical properties of gray and white matter brain tissue by indentation
  In: Journal of the Mechanical Behavior of Biomedical Materials (2015), p. 318-330
  ISSN: 1751-6161
  DOI: 10.1016/j.jmbbm.2015.02.024
• Budday S., Steinmann P., Goriely A., Kuhl E.:
  Size and curvature regulate pattern selection in the mammalian brain
  In: Extreme Mechanics Letters 4 (2015), p. 193-198
  ISSN: 2352-4316
  DOI: 10.1016/j.eml.2015.07.004
• Budday S., Steinmann P., Kuhl E.:
  Physical biology of human brain development
  In: Frontiers in Cellular Neuroscience 9 (2015), p. 1-13
  ISSN: 1662-5102
  DOI: 10.3389/fncel.2015.00257
• Budday S., Steinmann P., Kuhl E.:
  Secondary instabilities modulate cortical complexity in the mammalian brain
  In: Philosophical Magazine 95 (2015), p. 3244–3256
  ISSN: 1478-6435
  DOI: 10.1080/14786435.2015.1024184
• Budday S., Steinmann P., Kuhl E., Andres S.:
  Primary and secondary instabilities in soft bilayered systems
  GAMM Jahrestagung (Lecce)
  In: PAMM, Weinheim: 2015
  DOI: 10.1002/pamm.201510131
• Goriely A., Budday S., Kuhl E.:
  Chapter two-neuromechanics: From neurons to brain
  In: Advances in Applied Mechanics 48 (2015), p. 79--139
  ISSN: 0065-2156
  DOI: 10.1016/bs.aams.2015.10.002

2014

• Budday S., Kuhl E., Raybaud C.:
  A mechanical model predicts morphological abnormalities in the developing human brain
  In: Scientific Reports 4 (2014)
  ISSN: 2045-2322
  DOI: 10.1038/srep05644
• Budday S., Steinmann P., Kuhl E.:
  A mechanical approach to explain cortical folding phenomena in healthy and diseased brains
  GAMM 2014 (Erlangen, Germany, March 10, 2014 - March 14, 2014)
  In: PAMM, Erlangen, Germany: 2014
  DOI: 10.1002/pamm.201410038
• Budday S., Steinmann P., Kuhl E.:
  The role of mechanics during brain development
  In: Journal of the Mechanics and Physics of Solids 72 (2014), p. 75-92
  ISSN: 0022-5096
  DOI: 10.1016/j.jmps.2014.07.010